Center of Molecular Pathology Laboratory/ Department of Pathology PUBLICATIONS



Brebi, P; Ili, CG; Andana, A; Menzel, D; Lopez, J; Guzman, P; Melo, A; Buchegger, K; Roa, JC. (2017). Frequency of Human papillomavirus in women attending cervical cancer screening program in Chile. BMC CANCER, 17(): -

Brebi, P; Retamal, J; Mieville, C; León, D. Detección Molecular de Agentes Infecciosos de Transmisión Sexual en un Grupo de Hombres Sintomáticos y su Relación con la Conducta Sexual; REVISTA CHILENA DE INFECTOLOGIA, 2016, vol. 33, vol. suple. , n. 5, n. suple. p. 505 – 512

Buchegger, K; Riquelme, I; Viscarra, T; Ili, C; Brebi, P; Huang, THM; Roa, JC. (2017). Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor -Positive Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8): -

Buchegger, K; Silva, R; Lopez, J; Ili, C; Araya, JC; Leal, P; Brebi, P; Riquelme, I; Roa, JC. The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer.PATHOLOGY RESEARCH AND PRACTICE, 213(5): 476-482


Iturriaga, V; Bornhardt, T; Manterola, C; Brebi, P. Effect of hyaluronic acid on the regulation of inflammatory mediators in osteoarthritis of the temporomandibular joint: a systematic review. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 46(5): 590-595

Manterola, C; Otzen, T. Checklist for Reporting Results Using Observational Descriptive Studies as Research Designs. The MInCir Initiative. INTERNATIONAL JOURNAL OF MORPHOLOGY, 35(1): 72-76

Manterola, C; Otzen, T. Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ANNALS OF HEPATOLOGY, 16(3): 436-441

Manterola, C; Otzen, T. Dufourmentel Rhomboid Flap for Sacrococcygeal Pilonidal Sinus. Technical Details. INTERNATIONAL JOURNAL OF MORPHOLOGY, 34(4): 1207-1210

Manterola, C; Otzen, T. Early and Late Outcomes of Surgery of Non-Complicated Liver Hydatid. INTERNATIONAL JOURNAL OF MORPHOLOGY, 35(2): 556-563

Manterola, C; Otzen, T. Incidental Splenic Injury and Splenectomy. An Overview Based on Available Evidence. INTERNATIONAL JOURNAL OF MORPHOLOGY, 34(4): 1553-1560

Manterola, C; Otzen, T. Molecular Epidemiology of Cystic Echinococcosis: Genotypic Characterization in Humans and Different Livestock. INTERNATIONAL JOURNAL OF MORPHOLOGY, 34(4): 1472-1481

Manterola, C; Otzen, T. . Incidental Splenic Injury and Splenectomy. An Overview Based on Available Evidence. INTERNATIONAL JOURNAL OF MORPHOLOGY, 34(4): 1553-1560

Mathur, D; Riffo-Campos, AL; Castillo, J; Haines, JD; Vidaurre, OG; Zhang, F; Coret-Ferrer, F; Casaccia, P; Casanova, B; Lopez-Rodas, G. (2017). Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients. FRONTIERS IN CELLULAR NEUROSCIENCE, 11(): -

Mercogliano, MF; De Martino, M; Venturutti, L; Rivas, MA; Proietti, CJ; Inurrigarro, G; Frahm, I; Allemand, DH; Deza, EG; Ares, S; Gercovich, FG; Guzman, P; Roa, JC; Elizalde, PV; Schillaci, R. TNF alpha-Induced Mucin 4 Expression Elicits Trastuzumab Resistance in HER2-Positive Breast Cancer; CLINICAL CANCER RESEARCH 2017 (23): 636-648

Otzen, T; Manterola, C. Sampling Techniques on a Population Study. INTERNATIONAL JOURNAL OF MORPHOLOGY, 35(1): 227-232

Otzen, T; Manterola, C; Garcia-Dominguez, M. How to Evaluate and Interpret a Scientific Article About Therapy Or Therapeutic Procedures?. INTERNATIONAL JOURNAL OF MORPHOLOGY, 35(2): 776-784

Otzen, T; Sanhueza, A; Manterola, C; Hetz, M; Melnik, T. Transport accident mortality in Chile: trends from 2000 to 2012; CIENCIA & SAUDE COLETIVA 2016 (21): 3711-3718

Riffo-Campos, AL; Riquelme, I; Brebi-Mieville, P. Tools for Sequence-Based miRNA Target Prediction: What to Choose?; INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2016 (17): -

Rodriguez-Nunez, I; Manterola, C. Concurrent validity and interobserver reliability of the EPInfant pediatric perceived exertion rating scale among healthy Chilean children; ARCHIVOS ARGENTINOS DE PEDIATRIA 2016 (114): 343-346

Rodriguez-Nunez, I; Navarro, X; Gatica, D; Manterola, C. Effect of abdominal muscle training on respiratory muscle strength and forced expiratory flows in sedentary, healthy adolescents; ARCHIVOS ARGENTINOS DE PEDIATRIA 2016 (114): 434-440

Rojas, CAA; Ebi, D; Paredes, R; Acosta-Jamett, G; Urriola, N; Roa, JC; Manterola, C; Cortes, S; Romig, T; Scheerlinck, JP; Lightowlers, MW. High intraspecific variability of Echinococcus granulosus sensu stricto in Chile. PARASITOLOGY INTERNATIONAL, 66(2): 112-115

Tuncel, D; Roa, JC; Araya, JC; Bellolio, E; Villaseca, M; Tapia, O; Jang, KT; Quigley, B; Saka, B; Basturk, O; Sarmiento, J; Losada, HF; Patel, S; Reid, MD; Memis, B; Adsay, V. Poorly cohesive cell (diffuse-infiltrative/signet ring cell) carcinomas of the gallbladder: clinicopathological analysis of 24 cases identified in 628 gallbladder carcinomas; HUMAN PATHOLOGY 2017 (60): 24-31

Ugarte-Aviles, T; Manterola, C; Cartes-Velasquez, R; Otzen, T. Impact of proximity of thermoelectric power plants on bronchial obstructive crisis rates; BMC PUBLIC HEALTH 2017 (17): -



Benedetti V, Echeverria G, Riquelme I. Biomedical research in Latin America: we can do more. Lancet 2016;387(10022):941-941.

Buchegger K, Lopez J, Ili C, Riquelme I, Letelier P, Guzman P, et al. Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer. International Journal of Clinical and Experimental Medicine 2016;9(2):3025-3032.

Bellolio E, Pineda V, Burgos ME, Iriarte MJ, Becker R, Araya JC, et al. Predictive value of breast imaging report and database system (BIRADS) to detect cancer in a reference regional hospital. Revista Medica De Chile 2015;143(12):1533-1538.

Buchegger K, Ili C, Riquelme I, Letelier P, Corvalan AH, Brebi P, et al. Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line. Biological Research 2016;49.

Espinoza JA, Garcia P, Bizama C, Leal JL, Riquelme I, Weber H, et al. Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naive pT2 gallbladder adenocarcinoma patients. Histopathology 2016;68(5):722-728. 


Guzmán G, P., & Iriarte C, M. J. Carcinoma epidermoide de cuello uterino con extensión superficial a endometrio. Revista chilena de obstetricia y ginecología 2016;81(2):122-125.

Manterola C, Cartes-Velasquez R, Otzen T. Instructions for the Use of MInCiR Scale to Assess Methodological Quality in Prognosis Studies. International Journal of Morphology 2015;33(4):1553-1558.

Manterola C, Cartes-Velasquez R, Otzen T. Instructions for the Use of MInCir Scale to Assess Methodological Quality in Therapy Studies. International Journal of Morphology 2015;33(4):1463-1467.

Manterola C, Cartes-Velasquez R, Otzen T. Instructions for Using the MInCir Scale to Assess Methodological Quality in Diagnostic Accuracy Studies. International Journal of Morphology 2016;34(1):78-84.

Manterola C, Otzen T, Grp M. Esophageal Motility Disorders in Patients with Primary Sjogren's Syndrome. Study of Cases and Controls. International Journal of Morphology 2016;34(1):285-290.

Manterola, C., & Otzen, T. Gastrointestinal Stromal Tumors (GISTs): Single Center Experience Observed in a Small Series of Cases. International Journal of Morphology 2016;34(2):478-483.

Otzen T, Sanhueza A, Manterola C, Hetz M, Melnik T. Homicide in Chile: Trends 2000 - 2012 (vol 15, 312, 2015). Bmc Psychiatry 2016;16.

Riquelme I, Letelier P, Riffo-Campos AL, Brebi P, Roa JC. Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer. International Journal of Molecular Sciences 2016;17(3).

Riquelme I, Roa JC. Activated status of Hedgehog pathway in oral squamous cell carcinoma (OSCC): the door is still open. Translational Cancer Research 2016;5(1):14-16.

Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, et al. miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. Cellular Oncology 2016;39(1):23-33.

Rodriguez-Nunez I, Manterola C. Initial validation of the scale of peroeived exertion (EPInfant) in Chilean children. Biomedica 2016;36(1):29-38.




Asenjo-Lobos C, Manterola C. Critical Analysis of Literature. A Basic Process in Exercising Evidence Based Clinical Practice. International Journal of Morphology 2014;32(3):950-955.


Bizama C, Garcia P, Espinoza JA, Weber H, Leal P, Nervi B, et al. Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy. Cancer Treatment Reviews 2015;41(3):222-234


Cartes-Velasquez RA, Manterola C, Aravena P, Moraga J. Reliability and validity of MINCIR scale for methodological quality in dental therapy research. Brazilian Oral Research 2014;28(6):457-461

Elizalde P., Venturutti L., Romero L., Urtreger A., Chervo M., Cordo Russo R., Mercogliano M., Inurrigarro G., Pereyra M., Proietti C., Izzo F., Díaz Flaqué M., Sundblad V., Roa J., Guzmán P., Bal de Kier Joffé E., Charreau E., and Schillaci R. STAT3 regulates ERBB-2 expression and co-opts ERBB-2 nuclear function to induce mir-21 expression, PDCD4 downregulation and breast cancer metastasis. Oncogene. July 2015. doi: 10.1038/onc.2015.281


Espinoza J.A., García P., Bizama C., Leal J.L., Riquelme I., Weber H., Macanas P., Aguayo G., Viñuela E., Roa J.C., Nervi B. “Low expression of ENT1 is associated with poor prognosis in chemotherapy-naive pT2 gallbladder adenocarcinoma patients”. Histopathology. 2015


Hoffstetter R, Andana A, Guzman P, Ili CG, Retamal J, Mora B, et al. Human Papilloma Virus Frequency in non-Gynecological Tumors in the Araucania Region, Chile. International Journal of Morphology 2014;32(4):1254-1260


Ili, C., Brebi, P., Garcia, P., Leal, P., Lopez, J., Tapia, O., Letelier, P., Weber, H., Castillo, J., Roa, J.C. Effects of c-FLIPL knockdown in cervical uterine carcinoma cell lines. International Journal of Morphology. 2015; 33(2):638-646


Jadhav RR, Ye Z, Huang RL, Liu J, Hsu PY, Huang YW, Rangel LB, Lai HC, Roa JC, Kirma NB, Huang TH, Jin VX. Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer. Clin Epigenetics. 2015 Feb 24;7(1):13


Letelier P.* & Riquelme I.* “Implication of miRNAs in the pathogenesis of gallbladder cancer”. Austin Biomarkers & Diagnosis 2(1): 1014. 2015.


Manterola C, Alamo M, Horta J, Icarte MA, Riveros C, Ayala C, et al. Initial Results of Weight Loss Surgery with Vertical Gastrectomy and Jejunal By-pass. International Journal of Morphology 2014;32(3):991-997.


Manterola C, Asenjo-Lobos C, Otzen T. Hierarchy of evidence. Levels of evidence and grades of recommendation from current use. Revista Chilena De Infectologia 2014;31(6):705-718.


Manterola C, Otzen T. Experimental Studies 1st Part. Clinical Trial. International Journal of Morphology 2015;33(1):342-349


Manterola C, Otzen T. Experimental Studies 2nd Part. Quasi-experimental Studies. International Journal of Morphology 2015;33(1):382-387.


Manterola C, Otzen T, Calo L. Electronic Resources for Searching Health Scientific Information. Database Publication Type. International Journal of Morphology 2014;32(4):1484-1491


Manterola C, Urrutia S, Apodaca F. Therapeutic Alternatives for the Treatment of Infected Pancreatic Necrosis. An Overview. International Journal of Morphology 2014;32(4):1357-1364.


Manterola C, Urrutia S, Grp M. Post surgery morbidity in patients with complicated hepatic hydatidosis. Revista Chilena De Infectologia 2015;32(1):43-49.


Manterola C, Urrutia S, Mincir GRP. Infected Hepatic Echinococcosis: Results of Surgical Treatment of a Consecutive Series of Patients. Surgical Infections 2015;16(5):553-557.


Melo A, Artigas CG, Fritz C, Diaz P, Munoz S, Brebi P, et al. Hypermethylation of Tumor Suppressor Gene p53 in Chilean Pediatrics Patients Under 15 Years with Acute Lymphoblastic Leukemia. International Journal of Morphology 2014;32(4):1243-1247.


Nogueira L, Foerster C, Groopman J, Egner P, Koshiol J, Ferreccio C. Gallbladder Cancer Chile Working Group. Association of aflatoxin with gallbladder cancer in Chile. JAMA. 2015 May 26;313(20):2075-7.


Retamal J, Sanchez R, Brebi P. Non symptomatic sexually transmitted infections: urine sample allows an adequate detection. Revista Chilena De Infectologia 2015;32(3):283-288.


Riquelme I.*, Saavedra K.*, Espinoza J., Weber H., García P., Nervi B., Garrido M., Corvalán A., Roa J.C. and Bizama C. Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. Oncotarget, 5. 2015


Riquelme I.*, Tapia O.*, Leal P., Sandoval A., Letelier P., Buchegger K., Varga M., Espinoza J., Peek RM., Roa JC. “miR-101-2, miR-125b-2 and miR-451a act as tumor suppressor in gastric cancer through the regulation in the PI3K/AKT/mTOR pathway”. Cellular Oncology, 12 October 2015. DOI: 0.1007/s13402-015-0247-3


Saez PL, Bravo LA, Latsague MI, Toneatti MJ, Coopman RE, Alvarez CE, et al. Influence of in vitro growth conditions on the photosynthesis and survival of Castanea sativa plantlets during ex vitro transfer. Plant Growth Regulation 2015;75(3):625-639.


Subbannayya T, Leal-Rojas P, Barbhuiya MA, Raja R, Renuse S, Sathe G, Pinto SM, Syed N, Nanjappa V, Patil AH, Garcia P, Sahasrabuddhe NA, Nair B, Guerrero-Preston R, Navani S, Tiwari PK, Santosh V, Sidransky D, Prasad TS, Gowda H, Roa JC, Pandey A, Chatterjee A. Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. Cancer Biol Ther.2015;16(2):336-45.


Weber H., Leal P., Grez M., Stefan S., García P., Bizama C., Espinoza J.A., Riquelme I. and Roa J.C. “Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice”. Oncotarget, 11 September 2015. DOI: 10.18632/oncotarget.5047


Weber HL, Gidekel M, Werbajh S, Salvatierra E, Rotondaro C, Sganga L, et al. A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models. Clinical Cancer Research 2015;21(7):1665-1674.


Wichmann C, Quagliano-Lo Coco I, Yildiz O, Chen-Wichmann L, Weber H, Syzonenko T, et al. Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+hematopoietic progenitors. Leukemia 2015;29(2):279-289.


Xinyan Wu, Muhammad Saddiq Zahari, Binyun Ma, Ren Liu, Santosh Renuse, Nandini A Sahasrabuddhe, Lily Chen, Raghothama Chaerkady, Min-Sik Kim, Jun Zhong, Christine Jelinek, Mustafa A. Bharbuiya, Pamela Leal-Rojas, Yi Yang, Manoj Kumar Kashyap, Arivusudar Marimuthu, Min Ling, Mary Jo Fackler, Vanessa Merino, Zhen Zhang, Cynthia A Zahnow, Edward Gabrielson, Vered Stearns, Juan Carlos Roa, Saraswati Sukumar, Parkash S Gill and Akhilesh Pandey. global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways. Oncotarget 2015 Oct 6;6(30):29143-60.




Aravena PC; P Astudillo; C Manterola. Design of a scale for measuring post-surgical complications in third molar surgery. International Journal of Oral and MaxillofacialSurgery 2014 43(8);1008-1014


Bellolio E; O Tapia; MJ Iriarte. Mediastinal Castleman's disease. Report of one case. Revista Medica De Chile 2014 142(6);782-785


Manterola C; T Otzen. Critical Analysis of Biomedical Literature. International Journal of Morphology 2014 32(2);599-607.


Manterola C; T Otzen. Observational studies. The most commonly used designs in clinical research. International Journal of Morphology 2014 32(2);634-645


Manterola C; T Otzen; S Urrutia; MG Methodology; S Res. Risk factors of postoperative morbidity in patients with uncomplicated liver hydatid cyst. International Journal of Surgery 2014 12(7);695-699


Moraga J; C Manterola; R Cartes-Velasquez; ME Burgos; P Aravena; S Urrutia; M Grp. Instructions for the Use of MINCIR Scale to Assess Methodological Quality in Therapy Studies. International Journal of Morphology 2014 32(1);294-298


Otzen T; A Sanhueza; C Manterola; JA Escamilla-Cejudo. Trends in suicide mortality in Chile from 1998 to 2011. Revista Médica De Chile 2014 142(3);305-313


Pinto C; M Lechuga; E Bellolio; S Gonzalez; F Schafer. Giant congenital juvenile xanthogranuloma presenting as a yellowish atrophic plaque. Journal of Dermatology 2014 41(7);646-647


Sanhueza A; T Otzen; C Manterola; N Araneda. Statistical Approaches for Analyzing a Continuous Outcome in Experimental Studies. International Journal of Morphology 2014 32(1);339-350


Tapia O. Granulomatous appendicitis caused by sarcoidosis. Report of one case. RevistaMedica De Chile 2014 142(4);526-528


Tapia O; I Riquelme; P Leal; A Sandoval; S Aedo; H Weber; P Letelier, et al. The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance. VirchowsArchiv 2014 465(1);25-33.


Riquelme I; Saavedra K, Garcia P, Espinoza J Nervi B, Bizama C*, Roa JC*, Targetingspecific molecular pathwaysholdspromiseforadvancedgastric cancertherapyCancerInternational Journal of Molecular sciences In press Dec 2014 ISI 2,339.


"Melo A1, Artigas CG2, Fritz C1, Díaz P1, Muñoz S3, Brebi P1, Roa JC1-4.hypermethylation of tumor suppressor gene p53 in chileanpatientsunder 15 years with acute lymphoblastic leukemia."In pressIntJournalofMorphology In pressjune2014 ISI 0.2

Pablo Letelier1,2, Patricia García3, Pamela Leal1, Héctor Álvarez4, Carmen Ili1, Jaime López1 and Juan Carlos Roa1,3.mir-1 and mir-145 act as tumor suppressor micrornas in gallbladder cancerIn press International Journal of clinical and experimental pathology May 2014 ISI 2,04


Sahasrabuddhe NA, Barbhuiya MA, Bhunia S, Subbannayya T, Gowda H, Advani J, Shrivastav BR, Navani S, Leal P, Roa JC, Chaerkady R, Gupta S, Chatterjee A, Pandey A, Tiwari PK.Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics corresponding authorBiochemBiophys Res Commun. 2014 Apr 18;446(4):863-9. Doi: 10.1016/j.bbrc.2014.03.017. Epub 2014 Mar 20.ISI 2,4


Shindoh J1, de Aretxabala X, Aloia TA, Roa JC, Roa I, Zimmitti G, Javle M, Conrad C, Maru DM, Aoki T, Vigano L, Ribero D, Kokudo N, CapussottiL,Vauthey JN. Tumor location is a strong predictor of tumor progression and survival in t2 gallbladder cancer: an international multicenter study in press annals of surgeryAnn Surg. 2014 May 21. ISI 7,188


Cordo Russo RI, Béguelin W, DíazFlaqué MC, Proietti CJ, Venturutti L, Galigniana N, Tkach M, Guzmán P, Roa JC, O'Brien NA, Charreau EH, Schillaci R, Elizalde PV.Targeting erbb-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance Oncogene. 2014 Sep 1;0. Doi: 10.1038/onc.2014.272. [ ISI 8,55


Brebi P, Hoffstetter R, Andana A, Ili CG, Saavedra K, Viscarra T, Retamal J,Sanchez R, Roa JC.“Evaluation of zar1 and sfrp4 methylation status as potential biomarkers for diagnosis and progression in cervical carcinogenesis: exploratory study phase i”, Biomarkers. 2014 May;19(3):181-8 ISI 1.87


BrebiP, Maldonado L, Noordhuis MG, Ili C, Leal P, Garcia P, Brait M, Ribas J, Michailidi C, Perez J, Ethan Soudry, Oscar Tapia, Pablo Guzman, Sergio Muñoz, Leander Van Neste, Wim Van Criekinge, Rafael Irizarry, David Sidransky, Juan C Roa*, Rafael Guerrero-Preston.Genome-wide methylation profiling reveals zinc finger protein 516 (znf516) and fk-506-binding protein 6 (fkbp6) promoters frequently methylated in cervical neoplasia, associated with hpv status and ethnicity in a chilean*Epigenetics 2014; 9:0 - -1; PMID: 24241165; ISI 4.9


Villalon C, Quezada F, Hartmann J, Roa JC, Urrejola G. Synchronous ileocecaland duodenal tuberculosis: case report and review of the literature Int J bcolorectalDis. 2014 Aug;29(8):1027-8. Doi: 10.1007/s00384-014-1894-y. Epub 2014 May 10. ISI 2,415


Quezada N, Acevedo F, Marambio A, León F, Galindo H, Roa JC, JarufeN..Complete pathological response to imatinibmesylate in an extraintestinal gastrointestinal stromal tumor Int J Surg Case Rep. 2014 Aug 5;5(10):681-685. Doi: 10.1016/j.ijscr.2014.05.009. NO ISI


Pinto SM, Nirujogi RS, Rojas PL, Patil AH, Manda SS, Subbannayya Y, Roa JC, Chatterjee A, Prasad TS, Pandey A.Quantitative phosphoproteomic analysis of il-33 mediated signaling. Proteomics. 2014 Nov 4. Doi: 10.1002/pmic.201400303. [Epub ahead of print] pubmedPMID: 25367039. ISI 3,973


Melo A, Vásquez AM, Andana A, Matamala M, Pino T, Guzmán P, Hoffstetter R, iii C, Brebi P, Roa JC.[Genotyping of human papillomavirus in women under 25 years old treated in the screening program for cervical cancer]. Rev ChilenaInfectol. 2014 Oct;31(5):542-8.




Adsay V; B Saka; O Basturk; JC Roa. Criteria for Pathologic Sampling of Gallbladder Specimens. American Journal of Clinical Pathology 2013 140(2);278-280


Aravena P; R Cartes-Velasquez; C Manterola. Productivity and methodological quality of clinical articles in oral and maxillofacial surgery in Chile. Period 2001-2012. Revista Chilena De Cirugia 2013 65(5);382-388


Bellolio E; F Schafer; R Becker; MA Villaseca. Fulminant hepatic failure secondary to diffuse melanoma infiltration in a patient with a breast cancer history. Journal of Postgraduate Medicine 2013 59(2);164-166


Growth Factor Immunohistochemical Expression Is Associated With Gallbladder Cancer Progression. Archives of Pathology & Laboratory Medicine 2013 137(2);245-250


Gu F; MS Doderer; YW Huang; JC Roa; PJ Goodfellow; EL Kizer; THM Huang, et al. CMS: A Web-Based System for Visualization and Analysis of Genome-Wide Methylation Data of Human Cancers. PlosOne 2013 8(4)


Jarpa C; V Pineda; C Manterola; M Grp. Thickness of Carotid Intima-media as a Predictor of Cardiovascular Event. Systematic Review of the Literature. International Journal of Morphology 2013 31(1);293-300


Manterola C; P Astudillo; E Arias; N Claros; MMIC Grp. Systematic reviews of the literature: what should be known about them. Cirugia Espanola 2013 91(3);149-155

Manterola C; C Santander; T Otzen. How to assess and interpret a prognostic study. RevistaChilena De Cirugia 2013 65(1);77-84


Manterola C; P Astudillo. Checklist for Reporting of Descriptive Observational Studies. MINCIR Initiative. International Journal of Morphology 2013 31(1);115-120


Manterola C; S Urrutia; T Otzen. Effectiveness of mesh inguinal hernia repair. A systematic review. RevistaMedica De Chile 2013 141(7);932-939


Manterola C. Results of Laparoscopic Surgery in Nonparasitic Hepatic Cysts. International Journal of Morphology 2013 31(3);1116-1119


Manterola C; T Otzen; N Lorenzini; A Diaz; R Torres-Quevedo; N Claros. Initiatives for Reporting Biomedical Research Results with Different Types of Designs. International Journal of Morphology 2013 31(3);945-956


Manterola C; JC Roa; S Urrutia; M Grp. Treatment of the residual cavity during hepatic hydatidosis surgery: a cohort study of capitonnagevs.omentoplasty. Surgery Today 2013 43(12);1412-1418


MMIC Grp. Validation of a scale for assessing methodological quality of therapy studies. Pilotstudy. Revista Chilena De Cirugia 2013 65(3);222-227


Moraga J; R Cartes-Velasquez; S Urrutia; C Manterola; GMMI Cirug. Level of evidence of articles published in RevistaChilena de Cirugia. Assessment of theperiod 2007-2011. Revista Chilena De Cirugia 2013 65(4);301-306


Roa JC; O Tapia; C Manterola; M Villaseca; P Guzman; JC Araya; P Bagci, et al. Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor. VirchowsArchiv 2013 463(5);651-661


Tapia EO; CS Kam; TR San Martin. Vulvar Syringoma: Case Report and Literature Review. International Journal of Morphology 2012 30(3);924-926


Tapia O; S Kam; P Rifo; M Villaseca. Blasticplasmocytoid dendritic cell neoplasm. Report of one case. RevistaMedica De Chile 2012 140(10);1321-1324


Tapia O; E Bellolio; JC Araya. Splenic sarcoidosis: a rare cause of splenectomy. Revista Chilena De Cirugia 2013 65(3);208-209




Adsay V; KT Jang; JC Roa; N Dursun; N Ohike; P Bagci; O Basturk, et al. Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder (Neoplastic Polyps, Adenomas, and Papillary Neoplasms That Are >= 1.0 cm) Clinicopathologic and Immunohistochemical Analysis of 123 Cases. American Journal of Surgical Pathology 2012 36(9);1279-1301


Alamo M; M Sepulveda; J Gellona; M Herrera; C Astorga; C Manterola. Sleeve Gastrectomy with Jejunal Bypass for the Treatment of Type 2 Diabetes Mellitus in Patients with Body Mass Index < 35 kg/m(2). A cohort study. Obesity Surgery 2012 22(7);1097-1103


Arias E; P Astudillo; C Manterola; MMIC Grp. Second Neoplasm After Treatment of Localized Prostate Cancer. ActasUrologicasEspanolas 2012 36(10);583-589

Cartes-Velasquez R; J Moraga; P Aravena; C Manterola. Impact and visibility of RevistaChilena de Cirugia after its indexing on SciELO and ISI databases. Bibliometricanalysis. Revista Chilena De Cirugia 2012 64(6);511-515


Dursun N; OT Escalona; JC Roa; O Basturk; P Bagci; A Cakir; J Cheng, et al. Mucinous Carcinomas of the Gallbladder Clinicopathologic Analysis of 15 Cases Identified in 606 Carcinomas. Archives of Pathology & Laboratory Medicine 2012 136(11);1347-1358


Molina V; C Manterola; M Grp. Does alteration of extracellular matrix collagen degradation mechanisms manifested in the expression of MMP2 and TIMP2 in patients with primary inguinal hernia exists? International Journal of Morphology 2012 30(2);683-687

Tapia EO. Secondary intestinal tuberculosis: morphological findings in a fatal case. International Journal of Morphology 2012 30(1);347-353

Tapia EO. Tuberculous constrictive pericarditis. Case report and literature review. International Journal of Morphology 2012 30(2);696-700


Tapia EO; HR Becker; PL Antonio. Peribiliar gland hamartoma: report of two cases. International Journal of Morphology 2012 30(2);673-676


Tapia EO; CS Kam; VY Valenzuela. Cutaneous lymphoid hyperplasia (linfocitoma cutis) due to drugs: clinical and morphological findings. International Journal of Morphology 2012 30(1);170-175


Tapia EO; HM Villaseca; DC Manterola. Perforated gastric cancer. RevistaChilena De Cirugia 2012 64(5);457-461


Tapia O; P Jimenez. Intravascular large B cell lymphoma. Report of one case. RevistaMedica De Chile 2012 140(2);225-230


Tapia O; A Vidal; L Antonio. Brain hydatidosis. Report of four cases. Revista Medica De Chile 2012 140(3);358-363

Valenzuela Y; C Ramirez; E Bellolio. Subcorneal pustular dermatosis. Report of one case. Revista Medica De Chile 2012 140(5);633-636



Alvarez, Hector; Opalinska, Joanna; Zhou, Li; Sohal, Davendra; Fazzari, Melissa J.; Yu, Yiting; Montagna, Christina; Montgomery, Elizabeth A.; Canto, Marcia; Dunbar, Kerry B.; Wang, Jean; Carlos Roa, Juan; Mo, Yongkai; Bhagat, Tushar; Ramesh, K. H.; Cannizzaro, Linda; Mollenhauer, J.; Thompson, Reid F.; Suzuki, Masako; Meltzer, Stephen J.; Melnick, Ari; Greally, John M.; Maitra, Anirban; Verma, Amit. Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis. PLOS GENETICS Volume: 7 Issue: 3 Article Number: e1001356 DOI: 10.1371/journal.pgen.1001356 Published: MAR 2011 ISSN: 1553-7390


Burgos D, Maria Eugenia; Manterola D, Carlos; Sanhueza C, Antonio. Construction of a scale to assess methodological quality of diagnostic tests articles. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 5 Pages: 493-497 Published: OCT 2011 ISSN: 0379-3893


Guzman G, Pablo; Villaseca H, Miguel; Antonio P, Lilia; Araya O, Juan; Aravena M, Paola; Cravero P, Carla; Pino M, Pilar; Roa S, Juan.Oral and oropharingealsquamouscells carcinoma. Clinico-pathological study. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 3 Pages: 250-256 Published: MAY-JUN 2011 ISSN: 0379-3893


Losada M, Hector; Manterola D, Carlos; Pineda N, Viviana; Vial G, Manuel; Sanhueza C, Antonio Methodologicalquality in prognosticpapers (scaleMinCir Pr), Grp MINCIR MetodologiaInvest. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 6 Pages: 579-584 Published: DEC 2011 ISSN: 0379-3893


Manterola D, Carlos; Astudillo D, Paula. Iniciativa Mincir para el reporte de estudios observacionales descriptivos: Reporte preliminar. REVISTA CHILENA DE CIRUGÍA, Febrero 2011, vol.63, no.1, p.36-41.


Manterola D, Carlos; Moraga C, Javier; Urrutia B, Sebastian. Clinical and surgical aspects of hydatidosis, Grp MincirMetodologia Invest. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 6 Pages: 641-649 Published: DEC 2011 ISSN: 0379-3893


Manterola D, Carlos; Paula Astudillo D, Eu. Descriptive observational studies. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 1 Pages: 36-41 Published: FEB 2011 ISSN: 0379-3893


Manterola, Carlos; Moraga, Javier; Urrutia, SebastianContainedlaparostomywith a Bogota bag. Results of case series. CIRUGIA ESPANOLA Volume: 89 Issue: 6 Pages: 379-385 DOI: 10.1016/j.ciresp.2011.01.010 Published: JUN-JUL 2011 ISSN: 0009-739X


Manterola, Carlos; Vial, Manuel; Moraga, Javier; Astudillo, Paula. Analgesia in patients with acute abdominal pain. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (1): Art. No. CD005660 Julio 2011.


Manterola, Carlos; Vial, Manuel; Moraga, Javier; Astudillo, Paula. Analgesia in patients with acute abdominal pain. COCHRANE DATABASE OF SYSTEMATIC REVIEWS Issue: 1 Article Number: CD005660 DOI: 10.1002/14651858.CD005660.pub3 Published: 2011 ISSN: 1469-493X


Muñoz C, Cesar; Mansilla E, Juan; Roa S, Juan Carlos; Heider C, Claudia. Diverticular disease of the appendix in appendectomies REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 6 Pages: 604-608 Published: DEC 2011, ISSN: 0379-3893


Oscar Tapia, E.; Carlos Roa, Juan S. Gastrointestinal Stromal Tumors (GIST): Clinical-morphological Features and Immunohistochemical Profile. INTERNATIONAL JOURNAL OF MORPHOLOGY Volume: 29 Issue: 1 Pages: 244-251 Published: MAR 2011 ISSN: 0717-9502


Patel, Samip; Carlos Roa, Juan; Tapia, Oscar; Dursun, Nevra; Bagci, Pelin; Basturk, Olca; Cakir, Asli; Losada, Hector; Sarmiento, Juan; Adsay, Volkan. HyalinizingCholecystitis and Associated Carcinomas: Clinicopathologic Analysis of a Distinctive Variant of CholecystitisWith Porcelain-like Features and Accompanying Diagnostically Challenging Carcinomas. AMERICAN JOURNAL OF SURGICAL PATHOLOGY Volume: 35 Issue: 8 Pages: 1104-1113 DOI:10.1097/PAS.0b013e31822179cc Published: AUG 2011 ISSN: 0147-5185


Roa, Juan C.; Tapia, Oscar; Cakir, Asli; Basturk, Olca; Dursun, Nevra; Akdemir, Deniz; Saka, Burcu; Losada, Hector; Bagci, Pelin; Adsay, N. Volkan. .Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas . MODERN PATHOLOGY Volume: 24 Issue: 8 Pages: 1069-1078 DOI: 10.1038/modpathol.2011.68 Published: AUG 2011 ISSN: 0893-3952


Tapia E, Oscar; Bellolio J, Enrique; Carlos Roa S, Juan; Guzman G, Pablo; Villaseca H, Miguel; Carlos Araya O, Juan. Concordance between Gleason scores of trans rectal biopsies and the surgical piece of radical prostatectomy. REVISTA MEDICA DE CHILE Volume: 139 Issue: 2 Pages: 171-176 Published: FEB 2011 ISSN: 0034-9887.


Tapia E, Oscar; Carlos Roa S, Juan; Antonio P, Lilia Gallbladdercarcinosarcoma. Case report. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 1 Pages: 76-80 Published: FEB 2011 ISSN: 0379-3893


Tapia E, Oscar; Garcia M, Patricia; Manterola D, Carlos; Villaseca H, Miguel; Araya O, Juan Carlos; Roa S, Juan Carlos. Pathological features associated with survival in early gastric cancer. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 2 Pages: 162-169 Published: APR 2011 ISSN: 0379-3893


Tapia E, Oscar; Roa S, Juan Carlos. Tumores del Estroma Gastrointestinal (GIST): Características INTERNATIONAL JOURNAL OF MORPHOLOGY, Marzo 2011, vol.29, no.1, p.244-251.


Tapia E, Oscar; Roa S, Juan Carlos; Manterola D, Carlos; Puga A, Valentina; Villaseca H, Miguel; Araya O, Juan Carlos. Pathological factors associated with survival in advanced gastric cancer. REVISTA CHILENA DE CIRUGIA Volume: 63 Issue: 2 Pages: 154-161 Published: APR 2011 ISSN: 0379-3893


Tapia E, Oscar; Villaseca H, Miguel; Carlos Araya O, Juan; Carlos Roa R, Juan .Prognostic value of extracapsular lymph node involvement among patients with gastric cancer. REVISTA MEDICA DE CHILE Volume: 139 Issue: 8 Pages: 992-997 Published: AUG 2011 ISSN: 0034-9887


Tapia E., Óscar; Roa S., Juan Carlos; Antonio P, Lilia. Carcinosarcoma de la vesícula biliar: Caso clínico. REVISTA CHILENA DE CIRUGÍA, Febrero 2011, vol.63, no.1, p.76-80.


Tapia E., Oscar; Villaseca H., Miguel; Bellolio J., Enrique; Araya O, Juan Carlos; Roa S., Juan Carlos. Prognostic factors for gastric cancer without lymph node involvement . REVISTA MEDICA DE CHILE Volume: 139 Issue: 4 Pages: 432-438 Published: APR 2011 ISSN: 0034-9887