CV Dr. Fernando Lanas

  

ANTECEDENTES DE ESTUDIOS

TÍTULOS

UNIVERSIDAD

PAIS

AÑO

MÉDICO CIRUJANO

CONCEPCIÓN

CHILE

1974

ESPECIALISTA MEDICINA INTERNA

CHILE

CHILE

1977

RESEARCH FELLOW CARDIOLOGÍA

MIAMI

USA

1981

CLINICAL FELLOW CARDIOLOGÍA

MIAMI

USA

1982

GRADOS ACADÉMICOS

 

 

 

MASTER OF SCIENCES

PENSILVANIA

USA

1987

 

CARGOS HOSPITAL REGIONAL TEMUCO

Jefe Unidad de Cardiología: 1991-1996

Sub Jefe Unidad De Cuidados Intensivo: 2000- 2002

Sub Jefe SSRR Cardiología y Cirugía Cardíaca 2006-fecha

IV.- CARGOS UNIVERSIDAD DE LA FRONTERA

Profesor Titular: 01- 01- 1992, 11 hrs.

Director Unidad de Epidemiología Clínica 1990-1996

Director Departamento de Medicina Interna 1996-2000

Director Investigación Facultad de Medicina

Miembro de la Junta Directiva

Miembro del Consejo Académico

Miembro de CNP Facultad de Medicina 2012-

Subdirector Centro de Excelencia CIGES, 2006-fecha

 

MIEMBRO SOCIEDADES CIENTIFICAS

Sociedad Chilena de Cardiología. Past Presidente

American College of Cardiology. Fellow

Sociedad Europea de Cardiología. Fellow

American College of Physicians

Sociedad Médica de Santiago

Sociedad Chilena de Hipertensión

Sociedad Medica de Cautín. Presidente 1986             

 

OTROS CARGOS

Miembro Comité Asesor Ministerial del AUGE

Miembro de Academia de Medicina, Instituto de Chile

Coordinador del Comité de Epidemiología, Sociedad Interamericana de Cardiología

Miembro del Comité de Epidemiología, American Heart Association 2012-2014

Miembro Cardiovascular Working Group OMS

Comité Editorial “Heart Global”. Revista oficial Word Heart Federation

Miembro Consejo Editorial Medwave desde enero 2013

 

ACTIVIDADES DE INVESTIGACIÓN

ESTUDIOS MULTICENTRICOS INTERNACIONALES:  MIEMBRO DEL “STEERING COMMITTE” Y COORDINADOR NACIONAL

-Estudio INTERHEART. 1999-2003

-Estudio DREAM 2002-5 (Diabetes REduction Assessment with ramipril and rosiglitazone Medication)

-Estudio ACTIVE 2003-7 (atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events)

-Estudio PURE 2003-Fecha

-Estudio OASIS (Michelangelo) 5, 2003-2005 (Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes)

-Estudio OASIS (Michelangelo) 6 2003-2005 (Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction)

-Estudio OASIS 7 (CURRENT) Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes

-Estudio CORONARY: 2007- CABG Qff or QI Pump Revasculgization Study

-Estudio ARISTOTLE 2007-11 Apixaban versus Warfarin in Patients with Atrial Fibrillation

-Estudio AVERROES: 2008-10 Apixaban in Patients with Atrial Fibrillation

-Estudio INTERSTROKE 2008-

-Estudio TIDE-2010-2012 Thiazolidinedione Intervention with vitamin D Evaluation

-Estudio APOLLO 2010-2012  A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People

-Estudio PALLAS 2010-2011 Permanent Atrial fibriLLAtion outcome Study

using Dronedarone on top of standard therapy

-Estudio SIRS 2011-2014 Steroids in cardiac surgery trial

-Estudio ELIXA 2011-2015 Evaluation of LIXisenatide in Acute coronary syndrome

-Estudio EXSCEL 2011-2012 EXenatide Study of Cardiovascular Event Lowering Trial

 

NIH

NIH, BAA No. NHLBI-HV-09-12,

Global Health Project South American Centers of Excellence in Cardiovascular Health

Canadian Institutes of Health Research

Initiative for Cardiovascular Health  Management of Acute Myocardial Infarction in Low Resource setting

Canadian Institutes of Health Research. INTER-HEART: A global research program in cardiovascular disease prevention

Canadian Institutes of Health Research: INTERSTROKE. Risk factors for stroke

 

PROYECTOS FONDECYT

1.-Efectividad de digoxina en pacientes en insuficiencia cardíaca congestiva en ritmo sinusal. Investigador responsable, 1990

2.-Anticardiolipinas en Enfermedad reumática activa. Coinvestigador, 1992 # 0736/92

3.-Comparación de enalapril y digoxina en pacientes con insuficiencia cardíaca secundaria a insuficiencia mitral. Investigador principal , 1993, # 1930393

 

PROYECTOS FONIS

-2012. “Estudio costo-utilidad sobre el uso de anticoagulantes orales en pacientes con fibrilación auricular no valvular en Chile”,

 -2008. Prevención secundaria   en pacientes con  Infarto agudo del miocardio en  hospitales públicos después de la impleentación del GES: de la guía a la práctica FONIS SA08I20035

-2007: Factores sociales que condicionan el riesgo cardiovascular. SA06I20081

ROCKEFELLER FOUNDATION/ INCLEN

-Prevalencia de factores de riesgo cardiovascular en la ciudad de Temuco, 1990

-Patrones de prescripción en infarto del miocardio 1995

-Factores de riesgo de infarto del miocardio (InterHeart) 1999

-Factores de riesgo cardiovascular en población rural IX región, 2003-

DIUFRO

-Factores de riesgo de re-estenosis coronaria post angioplastia DI13-0012

-Desarrollo mental en niños expuestos a deficit de yodo, coinvestigador, 1991Vasodilatadores en pacientes con insuficiencia valvular, 1990

-Comparación de talio 201 y Tc 99m isonitrilo para la detección de miocardio hibernado, 1996

-Frecuencia del polimorfismo Glu298Asp del gen de la óxido nítrico sintasa en individuos con enfermedad coronaria y controles, de la ciudad de Temuco

 

PUBLICACIONES REVISTAS INDEXADAS (ISI) INTERNACIONALES

Lanas F, Serón P, Saavedra N, Ruedlinger J, Salazar L. Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects. Molecular Diagnosis & Therapy 2015. Jul 22, DOI 10.1007/s40291-015-0146-3

125.-Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, Seron P, Ahmed SH, Rosengren A, Kelishadi R, Rahman O, Swaminathan S, Iqbal R, Gupta R, Lear SA, Oguz A, Yusoff K, Zatonska K, Chifamba J, Igumbor E, Mohan V, Anjana RM, Gu H, Li W, Yusuf S; Prospective Urban Rural Epidemiology (PURE) Study investigators. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015 Jul 18;386(9990):266-73. doi:10.1016/S0140-6736(14)62000-6. Epub 2015 May 13. PubMed PMID: 25982160.

Bentley-Lewis R, Aguilar D, Riddle MC, Claggett B, Diaz R, Dickstein K, Gerstein HC, Johnston P, Køber LV, Lawson F, Lewis EF, Maggioni AP, McMurray JJ,  Ping L, Probstfield JL, Solomon SD, Tardif JC, Wu Y, Pfeffer MA; ELIXA Investigators. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo. Am Heart J. 2015 May;169(5):631-638.e7. doi: 10.1016/j.ahj.2015.02.002. Epub 2015 Feb 12. PubMed PMID: 25965710.

 

Avezum A, Lopes RD, Schulte PJ, Lanas F, Gersh BJ, Hanna M, Pais P, Erol C, Diaz R, Bahit MC, Bartunek J, De Caterina R, Goto S, Ruzyllo W, Zhu J, Granger CB, Alexander JH. Apixaban Compared with Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the ARISTOTLE Trial. Circulation. 2015 Jun 23. pii: CIRCULATIONAHA.114.014807. [Epub ahead of print] PubMed PMID: 26106009.


Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14. PubMed PMID: 25773268.


Lip GY, Rushton-Smith SK, Goldhaber SZ, Fitzmaurice DA, Mantovani LG, Goto S,  Haas S, Bassand JP, Camm AJ, Ambrosio G, Janský P, Al Mahmeed W, Oh S, van Eickels M, Raatikainen P, Steffel J, Oto A, Kayani G, Accetta G, Kakkar AK; GARFIELD-AF Investigators. Does sex affect anticoagulant use for stroke prevention in nonvalvular atrial fibrillation? The prospective global anticoagulant registry in the FIELD-Atrial Fibrillation. Circ Cardiovasc Qual Outcomes. 2015 Mar;8(2 Suppl 1):S12-20. doi: 10.1161/CIRCOUTCOMES.114.001556. Epub 2015 Feb 24. PubMed PMID: 25714828



Serón P, Pardo H, Lanas F. Cochrane corner: exercise for people with high cardiovascular risk. Heart. 2015 Feb 25. pii: heartjnl-2014-307123. doi: 10.1136/heartjnl-2014-307123. [Epub ahead of print] PubMed PMID: 25716192.



Zambrano T, Saavedra N, Lanas F, Caamaño J, Salazar LA. Efficacy of Ezetimibe Is Not Related to NPC1L1 Gene Polymorphisms in a Pilot Study of Chilean Hypercholesterolemic Subjects. Mol Diagn Ther. 2015 Feb;19(1):45-52. doi: 10.1007/s40291-014-0128-x. PubMed PMID: 25589339.



Rubinstein AL, Irazola VE, Calandrelli M, Elorriaga N, Gutierrez L, Lanas F, Manfredi JA, Mores N, Olivera H, Poggio R, Ponzo J, Seron P, Chen CS, Bazzano LA, He J. Multiple cardiometabolic risk factors in the Southern Cone of Latin America: a population-based study in Argentina, Chile, and Uruguay. Int J Cardiol. 2015 Mar 15;183:82-8. doi: 10.1016/j.ijcard.2015.01.062. Epub 2015 Jan 27. PubMed PMID: 25662056; PubMed Central PMCID: PMC4382451.

 

Lip GY, Connolly S, Yusuf S, Shestakovska O, Flaker G, Hart R, Lanas F, Xavier D, Eikelboom J; AVERROES Investigators. Modification of Outcomes With Aspirin or Apixaban in Relation to CHADS2 and CHA2DS2-VASc Scores in Patients With Atrial Fibrillation: A Secondary Analysis of the AVERROES Study. Circ Arrhythm Electrophysiol. 2013 Feb 1;6(1):31-8. doi: 10.1161/CIRCEP.112.975847. Epub 2013 Feb 6. PubMed PMID: 23390125.

 

López-Jaramillo P, Sánchez RA, Diaz M, Cobos L, Bryce A, Parra Carrillo JZ, Lizcano F, Lanas F, Sinay I, Sierra ID, Peñaherrera E, Bendersky M, Schmid H,Botero R, Urina M, Lara J, Foss MC, Márquez G, Harrap S, Ramírez AJ, Zanchetti A; on behalf of the Latin America Expert Group. Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome. J Hypertens. 2013 Feb;31(2):223-238. PubMed PMID: 23282894.

 

Dehghan M, Martinez S, Zhang X, Seron P, Lanas F, Islam S, Merchant AT Relative validity of an FFQ to estimate daily food and nutrient intakes for Chilean adults. Public Health Nutr. 2012 Sep 21:1-7.

 

Easton JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, Alings M, Goto S, Lewis BS, Rosenqvist M, Hanna M, Mohan P, Alexander JH, Diener HC; ARISTOTLE Committees and Investigators. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012
Jun;11(6):503-11.

 

ORIGIN Trial Investigators, Bosch J, Gerstein HC, Dagenais GR, Díaz R, Dyal L,Jung H, Maggiono AP, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, Yusuf S.n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl
J Med. 2012 Jul 26;367(4):309-18.

 

ORIGIN Trial Investigators, Gerstein HC, Bosch J, Dagenais GR, Díaz R, Jung H,Maggioni AP, Pogue J, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, Yusuf S. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med. 2012 Jul 26;367(4):319-28.

 

Hohnloser SH, Hijazi Z, Thomas L, Alexander JH, Amerena J, Hanna M, Keltai M, Lanas F, Lopes RD, Lopez-Sendon J, Granger CB, Wallentin L. Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrialfibrillation: insights from the ARISTOTLE trial. Eur Heart J. 2012 Aug 29.

 

Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, Straka Z,Piegas LS, Akar AR, Jain AR, Noiseux N, Padmanabhan C, Bahamondes JC, Novick RJ, Vaijyanath P, Reddy S, Tao L, Olavegogeascoechea PA, Airan B, Sulling TA,Whitlock RP, Ou Y, Ng J, Chrolavicius S, Yusuf S; CORONARY Investigators.Off-pump or on-pump coronary-artery bypass grafting at 30 days. N Engl J Med.
2012 Apr 19;366(16):1489-97. Epub 2012 Mar 26. PubMed PMID: 22449296.

 

Philco L P, Serón S P, Muñoz N S, Navia B P, Lanas Z F. Risk factors for metabolic Rev Med Chil. 2012 Mar;140(3):334-9. Spanish

 

Hankey GJ, Patel MR, Stevens SR, Becker RC, Breithardt G, Carolei A, Diener HC, Donnan GA, Halperin JL, Mahaffey KW, Mas JL, Massaro A, Norrving B, Nessel CC, Paolini JF, Roine RO, Singer DE, Wong L, Califf RM, Fox KA, Hacke W; ROCKET AF Steering Committee Investigators. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol. 2012 Apr;11(4):315-22.Epub 2012 Mar 7. PubMed PMID: 22402056.

 

Lawrence J, Pogue J, Synhorst D, Adalet K, Atar D, Avezum A, Budaj A, Commerford PJ, Dans AL, De Caterina R, Diener HC, Eikelboom J, Connolly SJ, Joyner CD, Hart RG, Lip GY, O'Donnell M, Hohnloser SH, Hankey GJ, Shestakovska O,Yusuf S; AVERROES steering committee and investigators. Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial. Lancet Neurol. 2012 Mar;11(3):225-31. Epub 2012 Feb 1. PubMed PMID: 22305462

 

Büller HR, Gallus AS, Pillion G, Prins MH, Raskob GE; Cassiopea Investigators.Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised,double-blind, double-dummy, non-inferiority trial. Lancet. 2012 Jan 14;379(9811):123-9. Epub 2011 Nov 28.

 

 

Lamy A, Devereaux PJ, Prabhakaran D, Hu S, Piegas LS, Straka Z, Paolasso E,Taggart D, Lanas F, Akar AR, Jain A, Noiseux N, Ou Y, Chrolavicius S, Ng J, Yusuf S. Rationale and design of The Coronary Artery Bypass Grafting Surgery Off or On
Pump Revascularization Study: A large international randomized trial in cardiac surgery. Am Heart J. 2012 Jan;163(1):1-6.

 

Connolly SJ, Camm AJ, Halperin JL.Lanas F, et als. Dronedarone in High-Risk Permanent Atrial Fibrillation. N Engl J Med. 2011 Nov 14 365(24):2268-7

 

Yusuf S, Islam S, Chow CK, Rangarajan S, Dagenais G, Diaz R, Gupta R,Kelishadi R, Iqbal R, Avezum A, Kruger A, Kutty R, Lanas F, Lisheng L, Wei L, Lopez-Jaramillo P, Oguz A, Rahman O, Swidan H, Yusoff K, Zatonski W, Rosengren A, Teo KK; on behalf of the Prospective Urban Rural Epidemiology (PURE) Study Investigators. Use of secondary prevention drugs for cardiovascular disease in
the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey. Lancet. 2011 Aug 26. 378(9798):1231-43.

 

Rubinstein AL, Irazola VE, Bazzano LA, Sobrino E, Calandrelli M, Lanas F, Lee AG, Manfredi JA, Olivera H, Ponzo J, Seron P, He J. Detection and follow-up of chronic obstructive pulmonary disease (COPD) and risk factors in the Southern Cone of Latin America. the pulmonary risk in South America (PRISA) study. BMC Pulm Med. 2011 Jun 1;11:34. PubMed PMID: 21627849; PubMed Central PMCID:
PMC3116480.

 

Anand SS, Dagenais GR, Mohan V, Diaz R, Probstfield J, Freeman R, Shaw J,Lanas F, Avezum A, Budaj A, Jung H, Desai D, Bosch J, Yusuf S, Gerstein HC.Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: the EpiDREAM cohort study. Eur J Cardiovasc Prev Rehabil. 2011 May 6. [Epub ahead of
print] PubMed PMID: 21551215.


Jolly SS, RIVAL trial group. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet. 2011 Apr 23;377(9775):1409-20. Epub 2011 Apr 4. Erratum in: Lancet. 2011 Apr 23;377(9775):1408. PubMed PMID: 21470671.

 

ACTIVE I Investigators, Yusuf S, Healey JS, Pogue J, Chrolavicius S, Flather M, Hart RG, Hohnloser SH, Joyner CD, Pfeffer MA, Connolly SJ. Irbesartan in patients with atrial fibrillation. N Engl J Med. 2011 Mar 10;364(10):928-38.

 

Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim KH, Lewis BS, Van Mieghem W, Lip GY, Kim JH, Lanas-Zanetti F, Gonzalez-Hermosillo A, Dans AL, Munawar M, O'Donnell M, Lawrence J, Lewis G, Afzal R, Yusuf S; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar3;364(9):806-17.

 

Serón P, Muñoz S, Lanas F. Levels of physical activity in an urban population from Temuco, Chile. Rev Med Chil. 2010 Oct;138(10):1232-9.

 

Bhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, Shook TL,Lapuerta P, Goldsmith MA, Laine L, Scirica BM, Murphy SA, Cannon CP; COGENT Investigators. Clopidogrel with or without omeprazole in coronary artery disease.N Engl J Med. 2010 Nov 11;363(20):1909-17

 

José Caamaño, Nicolás Saavedraa, Priscilla C. Jaramillo, Cecilia Lanas, Fernando Lanas, Luis A. Salazar, TP53 Codon 72 Polymorphism Is Associated with Coronary Artery Disease in Chilean Subjects. Medical Principles and practice 20:171-6 , 2011

 

CURRENT-OASIS 7 Investigators, Mehta SR, Bassand JP, Chrolavicius S, Diaz R,Eikelboom JW, Fox KA, Granger CB, Jolly S, Joyner CD, Rupprecht HJ, Widimsky P,Afzal R, Pogue J, Yusuf S. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010 Sep 2;363(10):930-42. Erratum in: N Engl J Med. 2010 Oct 14;363(16):1585. PubMed PMID: 208189

 

Mehta SR, Tanguay JF, Eikelboom JW, Jolly SS, Joyner CD, Granger CB, Faxon DP,Rupprecht HJ, Budaj A, Avezum A, Widimsky P, Steg PG, Bassand JP, Montalescot G, Macaya C, Di Pasquale G, Niemela K, Ajani AE, White HD, Chrolavicius S, Gao P,Fox KA, Yusuf S;CURRENT-OASIS 7 trial investigators. Double-dose versusstandard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010 Oct 9;376(9748):1233-43. PubMed PMID: 20817281.

 

O'Donnell M, Xavier D, Diener C, Sacco R, Lisheng L, Zhang H, Pias P, Truelsen T,Chin SL, Rangarajan S, Devilliers L, Damasceno A, Mondo C, Lanas F, Avezum A,Diaz R, Varigos J, Hankey G, Teal P, Kapral M, Ryglewicz D, Czlonkowska A,Skowronska M, Lopez-Jaramillo P, Dans T, Langhorne P, Yusuf S.Rationale and Design of INTERSTROKE: A Global Case-Control Study of Risk Factors for Stroke. Neuroepidemiology. 2010 Apr 8;35(1):36-44

 

Guzmán N, Lanas F, Salazar LA. Influence of Amerindian mitochondrial DNA haplogroups on thrombosis susceptibility and frequency of four genetic prothrombotic variants in Southern Chilean subjects. Clin Chim Acta. 2010 ;411(5-6):444-7.

 

Konstam MA, Neaton JD, Dickstein K, Drexler H, Komajda M, Martinez FA, Riegger GA, Malbecq W, Smith RD, Guptha S, Poole-Wilson PA; HEAAL Investigators. Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet. 2009 Nov 28;374(9704):1840-8. Epub 2009 Nov 16. PubMed PMID: 19922995.

 

Jaramillo Priscilla C., Lanas Cecilia, Lanas Fernando, Salazar Luis A., Polymorphisms of the NOS3 gene in Southern Chilean subjects with coronary artery disease and controls, Clinica Chimica Acta (2009), 411(3-4):258-62.

 

TIMACS Investigators. Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med. 2009 May 21;360(21):2165-75.

 

ACTIVE Investigators, Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med. 2009 May 14;360(20):2066-78.

 

Hohnloser SH, Crijns HJ, van Eickels M, Gaudin C, Page RL, Torp-Pedersen C,Connolly SJ; ATHENA Investigators. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med. 2009 Feb 12;360(7):668-78.

 

Caamaño J, Jaramillo PC, Lanas C, Lanas F, Salazar LA. Factor XII 46C --> T gene polymorphism in Chilean subjects with coronary artery disease and controls. Med Princ Pract. 2009;18(2):137-42.

 

Tardif JC, Ponikowski P, Kahan T; ASSOCIATE Study Investigators. Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial. Eur Heart J. 2009 Mar;30(5):540-8.

 

Mehta SR, CURRENT-OASIS 7 Steering Committee. Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy. Am Heart J. 2008 Dec;156(6):1080-1088.

 

Caamaño JM, Pacheco A, Lanas F, Salazar LA Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls.. Clin Chem Lab Med. 2008;46(11):1581-5.

 

DREAM Trial Investigators. Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial. Diabetes Care. 2008 May;31(5):1007-14.


Jaramillo PC, Lanas C, Lanas F, Salazar LA. -786T>C polymorphism of the endothelial nitric oxide synthase gene in Chilean subjects with coronary artery disease and controls. Clin Chim Acta. 2008;387:105-8.

 

Lanas F, Avezum A, Bautista LE, Diaz R, Luna M, Islam S, Yusuf S; INTERHEART Investigators in Latin America. Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study.
Circulation. 2007 Mar 6;115(9):1067-74.

 

DREAM Trial Investigators, Bosch J, Yusuf S, Gerstein HC, Pogue J, Sheridan P,Dagenais G, Diaz R, Avezum A, Lanas F, Probstfield J, Fodor G, Holman RR.Effect of ramipril on the incidence of diabetes.N Engl J Med. 2006 Oct 12;355(15):1551-62.

 

The Active Steering Committee; ACTIVE Investigators, Connolly S, Yusuf S,Budaj A, Camm J, Chrolavicius S,Lanas F et als Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events.Am Heart J. 2006 Jun;151(6):1187-93.

 

Jaramillo PC, Munoz M A, Lanas M C, Lanas Z F, Salazar LA Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. Clin Chim Acta. 2006 Sep;371(1-2):102-6

 

Jaramillo PC, Muñoz M A, Lanas M C, Lanas Z F, Salazar LA. Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. Clin Chim Acta. 2006 Sep;371(1-2):102-6. Epub 2006 Mar 2.PubMed PMID: 16616056.

 

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A,Pais P, Varigos J, Lisheng L; INTERHEART Study Investigators.Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.Lancet. 2004 Sep 11-17;364(9438):937-52.

 

Marti A, Pena-Marti G, Munoz S, Lanas F, Comunian G. Association between prematurity and maternal anemia in Venezuelan pregnant women during third trimester at labor.Arch Latinoam Nutr. 2001 Mar;51(1):44-8.

 

Figueroa FE, Fernandez MS, Valdes P, Wilson C, Lanas F, Carrion F, Berrios X, Valdes F. Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: long term follow up of patients with subclinical disease. Heart.2001 Apr;85(4):407-10.

 

Heller RF, O'Connell RL, Lim LL, Atallah A, Lanas F, Joshi P, Tatsanavivat P. Variation in stated management of acute myocardial infarction in five countries.Int J Cardiol. 1999 Jan;68(1):63-7.


INCLEN Multicenter Collaborative group. Body mass index and cardiovascular disease risk factors in seven asian and five latin american centers. Obesity research 1996;4: 221-28

 

INCLEN Multicenter Collaborative group. Socio-economic status and risk factors for cardiovascular disease. J Clin Epidemiol 1994; 47: 1401-9

 

Stockins BA, Lanas FT, Saavedra JG, Opazo JA. Prognosis in patients with diphtheric myocarditis and bradyarrhythmias: assessment of results of ventricular pacing.Br Heart J. 1994 Aug;72(2):190-1.

 

INCLEN Multicenter Collaborative group. Risk factors for cardiovasculardisease in the developing world. J Clin Epidemiol 1992; 45: 841-7

 

Lanas F. Right bundle branch block and survival after myocardial infarction Commentary. ACP Journal Club 1991 59

 

Lanas F. Value of echocardiography in infective endocarditis.ACP Journal Club 1991 27


PUBLICACIONES ISI NACIONALES

Philco L P, Serón S P, Muñoz N S, Navia B P, Lanas Z F. [Risk factors for metabolic syndrome in a case control study in Temuco, Chile]. Rev Med Chil. 2012 Mar;140(3):334-9.


Nazzal N C, Campos T P, Corbalán H R, Lanas Z F, Bartolucci J J, Sanhueza C P,Cavada Ch G, Prieto D JC; Grupo GEMI; Departamento de Estudios Multicéntricos,Sociedad Chilena de Cardiología y Cirugía Cardiovascular. [The impact of Chilean health reform in the management and mortality of ST elevation myocardialinfarction (STEMI) in Chilean hospitals]. Rev Med Chil. 2008 Oct;136(10):1231-9.


Lanas F, Potthoff S, Mercadal E, Santibáñez C, Lanas A, Standen D. [Individual and population risk in acute myocardial infarction: the Chilean INTERHEART study]. Rev Med Chil. 2008 May;136(5):555-60.

 

Nazzal N C, Campos T P, Corbalán H R, Lanas Z F, Bartolucci J J, Sanhueza C P,Cavada Ch G, Prieto D JC; Grupo GEMI; Departamento de Estudios Multicéntricos, Sociedad Chilena de Cardiología y Cirugía Cardiovascular. The impact of Chilean health reform in the management and mortality of ST elevation myocardial infarction (STEMI) in Chilean hospitals]. Rev Med Chil. 2008 Oct;136(10):1231-9.

 

Prieto JC, Sanhueza C, Martínez N, Nazzal C, Corbalán R, Cavada G, Lanas F,Bartolucci J, Campos P, Mortalidad intrahospitalaria en hombres y mujeres según terapias de reperfusión en infarto agudo del miocardio con supradesnivel del ST Rev Med Chil. 2008 Feb;136(2):143-50.

 

Raffo C, Bartolucci J, Corbalan R, Aninat M, Torres H, Prieto JC, Lanas F,Chavez E, Cumsille F, Nazzal C; Grupo de Estudio Multicentrico del Infarto. Usefulness of thrombolytic therapy with low doses of streptokinase in acute myocardial infarction. Rev Med Chil. 2006 Oct;134(10):1249-57.

 

Lanas F, Del Solar J, Maldonado M, Guerrero MA, Espinoza F.[Prevalence of risk factors to cardiovascular disease in group of Chilean employees] Rev Med Chil. 2003 Feb;131(2):129-34.

 

Corvalán R, Nazzal C, Prieto JC, Chávez E, Lanas F Reducción de la mortalidad por infarto del miocardio en los hospitales chilenos. Rev Med Chil. 2002 Apr;130(4):368-78.

 

Prieto JC, Corbalan R, Nazzar C, Chavez E, Lanas F, Bartolucci J, Cumsille F. Cambios en los patrones de prescripción en el Infarto Agudo del Miocardio. Comparación de 2 periodos Rev Med Chil. 2001 May;129(5):481-8.

 

Prieto JC, Corbalan R, Chavez E, Lanas F, Cumsille F, Nazzal C. Infarto agudo del miocardio en hospitales chilenos. Resultados finales del estudio GEMI. Rev Med Chil. 1999 Jul;127:763-74. 9

 

Lanas F, Garces E, Eggers G, Montecinos A, Diaz M, Gamboa C, Stockins B. Comparación del efecto de digoxina y enalapril en el tratamiento de la insuficiencia cardíaca secundaria a insuficiencia mitral. Rev Med Chil. 1998 Mar;126(3):251-7.

 

Stockins B, Larenas G, Charles M, Standen D, Espinoza O, Illesca M, Opazo
JA, Carrasco B, Lanas F, Davis M. Niveles de lípidos séricos y presión arterial en población mapuche en la Región de la Araucanía. Chile. Rev Med Chil.1998 Nov;126(11):1291-9

 

Lanas F, Salvatici R, Castillo G, Montecinos A, Stockins B, Molina E. Comparación entre digoxina y atenolol en la fibrilación auricular crónica.Rev Med Chil. 1995 Oct;123(10):1252-62.

 

Lanas F, Standen D, Steinmann WC, Montecinos A, Stockins B. La digoxina es efectiva en pacientes en insuficiencia cardíaca en ritmo sinusal.Rev Med Chil. 1994 Oct;122(10):1147-52.

 

Lanas F, Davis MR, Standen D, Illesca M, Doghetti J, Stockins B. Prevalencia de factores de riesgo cardiovascular en la ciudad de Temuco. Rev Med Chil. 1991 Mar;119(3):247-51.

 

Lanas F, Eggers G, Stockins B, Iturriaga J. Pronóstico post infarto agudo del miocardio.Rev Med Chil. 1990 Jul;118(7):759-63.

 

Riedemann P, Lanas F, Montecinos A, Inostroza J, Rodriguez J, Sandoval K. Frecuencia ventricular en pacientes en insuficiencia cardíaca con fibrilación auricular. ¿Un índice adecuado de digitalización? Rev Med Chil. 1988 Jul;116(7):651-4.

 

Lanas F, Stockins B, Gamboa C, Salvatici R, Opaso JA, Saavedra J. Ecocardiografía en la endocarditis bacteriana. Rev Med Chil. 1985 Mar;113(3):203-6

 

Stockins B, Opazo J, Gamboa C, Salvatici R, Lanas F, Saavedra J, Curimil N,Karstegl P. Efectos hemodinámicos de nifedipino en el infarto agudo del miocardio.Rev Med Chil. 1985 Mar;113(3):193-6.

 

Lanas F, Stokins B, Saavedra J, Opazo JA, Salvatici R, Schulthess L. Hidralazina en pacientes con insuficiencia aórtica severa. Efectos en presión y volumen ventricular.Rev Med Chil. 1982 Jan;110(1):15-20.

 

Lanas F, Oliva ME, Pantoja M, Salvatici R, Opazo JA, Stockin B, Saavedra J.Programa de prevención de recurrencias de enfermedad reumática. IX Región, Chile.Rev Med Chil. 1981 Aug;109(8):763-8.

 

Stockins B, Saavedra J, Opazo JA, Salvatici R, Lanas F. Ecocardiografía contrastada en el diagnóstico de comunicación interauricular Rev Med Chil. 1980 Jul;108(7):612-

 

Lanas F, Salvatici R, Opazo JA, Stockins B, Saavedra J, Schulthess L. Efectos hemodinámicos de la hidralazina en reposo y ejercicio en pacietnes en insuficiencia cardíaca congestiva.Rev Med Chil. 1980 Jul;108(7):599-604.

 

Lanas F, Salvatici R, Opazo JA, Saavedra J, Iturriaga J. Tratamiento de la insuficiencia cardíaca avanzada con hidralazina e isorbide dinitrato.Rev Med Chil. 1979 Oct;107(10):926-30.

 

Miranda V, Saavedra J, Opazo JA, Stockins B, Contreras M, Lanas F.Evaluación clínica y hemodinámica del tratamiento con isosorbide dinitrato en insuficiencia cardíaca. Rev Med Chil. 1979 Aug;107(8):721-3.

 

Lanas F, Reginato A, Martinez V, Naquira N, Duran G, Bianchi C, Galdames M,Garcia A. Patología de las válvulas cardíacas: correlación con los hallazgos clínicos.Rev Med Chil. 1979 May;107(5):406-12

 

Baeza H, Chamorro G, Lanas F, Escobar E. Medición del gasto cardíaco por termodilución. Correlación con el método directo de Fick.
Rev Med Chil. 1978 Oct;106(10):784-7.

 

Lanas F, Reginato A. Sindrome de Marfán. Rev Med Chil. 1978 Jun;106(6):428-34.

 

Reginato A, Lanas F, Blumel E. Compromiso cardiovascular en enfermedades reumáticas.Rev Med Chil. 1978 May;106(5):379-86.

 

Concha E, Zavala C, Veit O, Lanas F. Hipotensión postural en pacientes diabéticos Rev Med Chil. 1977 Mar;105(3):168-70.

 

PUBLICACIONES NO ISI

Lanas F. Factores de riesgo cardiovascular en Chile. Rev Chil Cardiol 2008; 27: 79-81

 

Salazar L, Zambrano T, Jaramillo P, Lanas F. Frecuencia de la variante 23968A>G del gen PCSK9 en individuos chilenos con enfermedad coronaria confirmada por angiografía y controles. Rev Chil Cardiol 2008; 27: 43-50

 

Christian L. Herrera, Priscilla C. Jaramillo, Fernando Lanas, Luis A. Salazar. Frecuencia de la variante C373G del gen PECAM-1 en individuos chilenos con enfermedad coronaria y controles Revista Chilena de Cardiología2007; - Vol. 26 Nº4, pag 399

 

Prieto JC, Corvalán R, Bartolucci J, Nazzal C, Chavez E, Lanas F Jara P, Cunsille F. Cambios en el Manejo Intrahospitalario del Infarto Agudo del Miocardio en Hospitales Chilenos. La experiencia del grupo GEMI. Rev Chilena Cardiol 2003; 22: 31-36

 

Prieto JC, Corvalán R, Bartolucci J, Nazzal C, Montaño R, Lanas F, Chacez E, Jara P.Trombolisis en el Infarto Agudo del Miocardio en Hospitales Chilenos. La experiencia del grupo GEMI. Rev Chilena Cardiol 2003; 22: 23-30

 

Lanas F, Carrillo H, Lanas A, Miranda V. Infarto agudo del miocardio en el Hospital Regional Temuco. Rev Med Sur 2001; 23:34-9

 

Montecinos A, Lanas F, Stockins B, Millaqueo C. Utilidad de la tomografía de perfusión miocárdica para la detección de miocardio hibernado. Rev Chil Cardiol 2001; 20: 29-34

 

Lanas F, Carrillo H, Lanas A, Miranda R, Stockins B. Variación estacional y semanal del infarto agudo del miocardio en la IX Región de Chile. Rev Chil Cardiol 2001; 20: 35-40

 

Lanas F. Síndromes coronarios agudos. Medicina Intensiva, 2001; 16: 80-86

 

Lanas F. La conferencia Zapata Diaz 1999. Rev Chil Cardiol 1999; 18: 215-6

 

Lanas F. Uso de beta bloqueadores en insuficiencia cardíaca. Rev Med Sur 1999; 21:21-4

 

Lanas F, Prieto JC, Chávez E, Corvalán C, Cumsille F. Uso de bloqueadores beta adrenérgicos en el infarto del miocardio Rev Chil Cardiol 1998; 17: 205-11

 

Lanas F, Cofré P, Moreno M. Infarto del miocardio: Características clínicas, tratamiento y pronóstico. Rev Med Sur 1997 34-36

 

Grupo de Estudios Multicéntrico del Infarto: Farmacoepidemiología del Infarto Agudo del miocardio en 33 hospitales Chilenos Rev Chilena Cardiol1995; 14: 11-19

 

Stockins B, Lanas F, Salvatici R, Standen D. Evaluación hemodinámica de los nitratos transdérmicos en pacientes con insuficiencia cardíaca. Bol Cardiol 1988; 7: 27

 

Saavedra J, Morales O, Opazo JA, Salvatici R, Stockins B, Lanas F, Gamboa C.Estudio de la utilidad de la estimulación aurículo ventricular secuencial en pacientes con marcapaso e insuficiencia cardíaca. Rev Med Sur 1987; 12: 12-18

 

Sierralta P; Riedemann P. Abarca C, Lanas F. Correlación diagnóstico electrocardiográfico versus diagnóstico ecocardiográfico de reacción auricular izquierda. Rev Med Sur 1986; 11: 16-19

 

Stockins B, Lanas F, Figueroa G, Salinas V. Pronóstico de las bradiarritmia en la miocarditis diftérica. Rev Med Sur 1986; 11: 5-7

 

Lanas F, Castillo C, Salvatici R. Evaluación no invasiva del infarto agudo del miocardio. Rev Med Sur 1985; 10: 51-55

 

Stockins B, Gamboa C, Yanine G, Salvatici R, Lanas F, Opazo JA, Saavedra J.Función diastólica en pacientes portadores de hipertrofia de diversas etiologías. Rol de 2 antagonistas de calcio. Rev Med Sur 1984; 9:5-9

 

Lanas F. Indicación quirúrgica en valvulopatías. Rev Med Sur 1984;9:43-48

 

Stockins B, Saavedra J, Opazo JA, Salvatici R, Lanas F. Ecocardiografía contrastada. Frontera 1982; 15-20

 

Corvalán J, Lanas F, González E, Díaz A, Rodriguez I. Rol del timo en eldesarrollo de la capacidad inmunológica. Medicina (Universidad de Concepción) 1973; 3: 227-32

 

Abstracts

Congreso Europeo de Cardiología 2008C. Nazzal, R. Corbalan, P. Campos, J. Bartolucci, G. Cavada, JC. Prieto, F. Lanas

 

In-hospital mortality in diabetic and non-diabetic patients with AMI : a time trend analysis based on the Chilean National Acute Myocardial Infarction Register, 2001-2006

 

C. Nazzal, R. Corbalan, P. Campos, J. Bartolucci, JC. Prieto, P. Sanhueza, F. Lanas Is it possible to reduce in-hospital mortality in women with ST segment elevation myocardial infarction (STEMI)? : Impact of the Chilean health sector reform

 

Congreso mundial de cardiología B Aires 2008

Lanas F, Prieto JC, Nazzal C, Serón P, Campos P, Bartolucci R, Corvalán R, Prognosis of acute myocardial infarction in the elderly in Chile fron 1993 to 2006 

J Caamaño, P Jaramillo, C Lanas, F Lanas, A Salazar.Absence of association between factor XII 36C>T gene polymorphism and coronary artery disease in Chilean subjects

 

Rosales A, Pacheco N, Saavedra F, Lanas F, Salazar LO. Frequency of common variants of ABCB1, CYP3A4 and CYP3A5 genes in Chilean subjects with primary hypercholesterolemia

 

Salazar L, Hernández A, Cuevas A, Jaramillo P, Lanas C, Lanas F. The presence of C allele for 765G>C common variant of cox-2 gene constitutes a protector factor against coronary artery disease.

 

Congreso Eupopeo de Cardiología 2011 Paris. L. Sepulveda Morales (Clinica Alemana, Santiago /Chile), J.L. Vukasovic (Hospital of Salvador, Santiago /Chile), R. Concepcion (Hospital Dipreca, Santiago /Chile), E. Garces (Regional Clinical Hospital Valdivia, Valdivia /Chile), F. Lanas (Regional Hospital of Temuco, Temuco /Chile), P. Castro (Catholic University Clinical Hospital, Santiago /Chile), V. Rossel (Hospital of Salvador, Santiago /Chile), P. Bilbao (Clinica Alemana, Santiago /Chile), R. Larrea (Clinica Davila, Santiago/Chile) Clinical characteristics of heart failure in Chile. Chilean registry of heart failure: ICARO 2002- 2010

  

Congreso Europeo de Cardiologìa 2008. Lanas (/), Prieto (/), Corvalan (/), Nazzal (/), Campos (/), Seron (/), Bartolucci (/)Improved therapy and outcome for patients with acute myocardial infarction in the chilean registry of myocardial infarction

 

Nazzal (/), Corbalan (/), Campos (/), Bartolucci (/), Prieto (/), Sanhueza (/), Lanas (/)Is it possible to reduce in-hospital mortality in women with ST segment elevation myocardial infarction (STEMI)? Impact of the Chilean health sector reform

 

Nazzal (/), Corbalan (/), Campos (/), Bartolucci (/), Cavada (/), Prieto (/), Lanas (/)In-hospital mortality in diabetic and non-diabetic patients with AMI: a time trend analysis based on the Chilean National Acute Myocardial Infarction Register, 2001-2006